Lu Chen headshot.jpg

Lu Chen

Ph.D. in Biochemistry and Molecular Biology

fccc logo.png

Assistant Professor

Cancer Signaling and Epigenetics Program

Cancer Epigenetics Institute,
Fox Chase Cancer Cancer




Stanford Cancer Institute,
Stanford University School of Medicine


stanford logo.png

Postdoctoral Fellow

Stanford University,
Department of Biochemistry
Department of Medicine-Hematology 
Steven Artandi laboratory,
SCI fellowship in cancer research


stowers new logo.png

Stowers Institute for Medical Research
University of Kansas Medical Center.
Joan and Ronald Conaway laboratory,
PhD Thesis: Structural and functional analysis on human INO80 chromatin remodeling complexes.

PhD (honors) in Biochemistry


whu logo.jpg

Wuhan University and 

Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Hong Tang laboratory,

Thesis: A role of CD40 and lipid rafts in atherosclerosis.

BS in Biological Sciences



Key Publications

Snow Covered Field
cell logo.png

Cell. 2018 Jun 28;174(1):218-230.e13. 

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen, Caitlin M Roake, Adam Freund, Pedro J Batista, Siqi Tian, Yi A Yin, Chandresh R Gajera, Shengda Lin, Byron Lee, Matthew F Pech, Andrew S Venteicher, Rhiju Das, Howard Y Chang, Steven E Artandi

cell rep logo.png

Cell Rep. 2020 Feb 4;30(5):1358-1372.e5. 

Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa

STAR protocols.jpg

STAR Protocols. 2021 Jun 18;2(2):100477.

Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE

Lu Chen ✉, Howard Y Chang, Steven E Artandi
✉ Co-corresponding author

dna repair logo.jpg

DNA Repair (Amst). 2021 Jan;97:103022. 

A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma

Lu Chen ✉, Rebecca R Bellone, Yan Wang, Moriel Singer-Berk, Kaoru Sugasawa, James M Ford, Steven E Artandi
✉ Corresponding author

pnas logo.jpg

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20497-502.

Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex

Lu Chen, Ronald C Conaway, Joan W Conaway

JBC logo.jpg

J Biol Chem. 2011 Apr1;286(13):11283-9. 

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling

Lu Chen, Yong Cai, Jingji Jin, Laurence Florens, Selene K Swanson, Michael P Washburn, Joan W Conaway, Ronald C Conaway

jove logo.png

J Vis Exp. 2014 Oct25;(92): 51720.

Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes

Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway

jove logo.png

J Vis Exp. 2014 Oct 25;(92):e51721.

Biochemical assays for analyzing activities of ATP-dependent chromatin remodeling enzymes

Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway