Lu Chen headshot.jpg

Lu Chen

Ph.D. in Biochemistry and Molecular Biology

fccc logo.png

Assistant Professor

Cancer Signaling and Epigenetics Program

Cancer Epigenetics Institute,
Fox Chase Cancer Cancer

2021-

stanford%20SOM_edited.png

Instructor

Stanford Cancer Institute,
Stanford University School of Medicine

2020-2021

stanford logo.png

Postdoctoral Fellow

Stanford University,
Department of Biochemistry
Department of Medicine-Hematology 
Steven Artandi laboratory,
SCI fellowship in cancer research

2013-2020

stowers new logo.png

Stowers Institute for Medical Research
University of Kansas Medical Center.
Joan and Ronald Conaway laboratory,
PhD Thesis: Structural and functional analysis on human INO80 chromatin remodeling complexes.

PhD (honors) in Biochemistry

2007-2013

whu logo.jpg

Wuhan University and 

Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Hong Tang laboratory,

Thesis: A role of CD40 and lipid rafts in atherosclerosis.

BS in Biological Sciences

2002-2006

 

Key Publications

 
Snow Covered Field
cell rep logo.png

Cell Rep. 2020 Feb 4;30(5):1358-1372.e5. 

Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa

cell rep logo.png

Cell Rep. 2020 Feb 4;30(5):1358-1372.e5. 

Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa

STAR protocols.jpg

STAR Protocols. 2021 Jun 18;2(2):100477.

Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE

Lu Chen ✉, Howard Y Chang, Steven E Artandi
✉ Co-corresponding author

dna repair logo.jpg

DNA Repair (Amst). 2021 Jan;97:103022. 

A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma

Lu Chen ✉, Rebecca R Bellone, Yan Wang, Moriel Singer-Berk, Kaoru Sugasawa, James M Ford, Steven E Artandi
✉ Corresponding author

pnas logo.jpg

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20497-502.

Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex

Lu Chen, Ronald C Conaway, Joan W Conaway

JBC logo.jpg

J Biol Chem. 2011 Apr1;286(13):11283-9. 

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling

Lu Chen, Yong Cai, Jingji Jin, Laurence Florens, Selene K Swanson, Michael P Washburn, Joan W Conaway, Ronald C Conaway

jove logo.png

J Vis Exp. 2014 Oct25;(92): 51720.

Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes

Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway

jove logo.png

J Vis Exp. 2014 Oct 25;(92):e51721.

Biochemical assays for analyzing activities of ATP-dependent chromatin remodeling enzymes

Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway

cell logo.png

Cell. 2018 Jun 28;174(1):218-230.e13. 

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen, Caitlin M Roake, Adam Freund, Pedro J Batista, Siqi Tian, Yi A Yin, Chandresh R Gajera, Shengda Lin, Byron Lee, Matthew F Pech, Andrew S Venteicher, Rhiju Das, Howard Y Chang, Steven E Artandi

NAR.png

Nucleic Acids Research. 2022 Aug 10; gkac659

TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration

Lu Chen✉, Caitlin M Roake, Paolo Maccallini, Francesca Bavasso, Roozbeh Dehghannasiri, ... , Marie A Kobin, ..., Yunming Wu, ..., Maurizio Gatti, Steven Artandi, Grazia D Raffa

✉ Co-corresponding author