Lu Chen

Ph.D. in Biochemistry and Molecular Biology

faculty page

Academic Tree

Adjunct Faculty

Dept. of Biochemistry and Molecular Biology

Molecular & CellBiology & Genetics grad program

Drexel University Colledge of Medicine

2024-

Adjunct faculty

Dept of Cancer and Cellular Biology

Lewis Katz School of Medicine

Temple University

2022-

Assistant Professor

Nuclear Dynamics and Cancer Program

Cancer Epigenetics Institute,
Fox Chase Cancer Cancer

2021-

Instructor

Stanford Cancer Institute,
Stanford University School of Medicine

2020-2021

Postdoctoral Fellow

Stanford University,
Department of Biochemistry
Department of Medicine-Hematology
Steven Artandi laboratory,
SCI fellowship in cancer research

2013-2020

Stowers Institute for Medical Research
University of Kansas Medical Center.
Joan and Ronald Conaway laboratory,
PhD Thesis: Structural and functional analysis on human INO80 chromatin remodeling complexes.

PhD (honors) in Biochemistry

2007-2013

Wuhan University and

Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Hong Tang laboratory,

Thesis: A role of CD40 and lipid rafts in atherosclerosis.

BS in Biological Sciences

2002-2006

About the PI: CV

Key Publications

About the PI: Publications

Cell Rep. 2020 Feb 4;30(5):1358-1372.e5.

Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa

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Cell Rep. 2020 Feb 4;30(5):1358-1372.e5.

Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation

Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa

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STAR Protocols. 2021 Jun 18;2(2):100477.

Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE

Lu Chen ✉, Howard Y Chang, Steven E Artandi
✉ Co-corresponding author

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DNA Repair (Amst). 2021 Jan;97:103022.

A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma

Lu Chen ✉, Rebecca R Bellone, Yan Wang, Moriel Singer-Berk, Kaoru Sugasawa, James M Ford, Steven E Artandi
✉ Corresponding author

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Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20497-502.

Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex

Lu Chen, Ronald C Conaway, Joan W Conaway

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J Biol Chem. 2011 Apr1;286(13):11283-9.

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling

Lu Chen, Yong Cai, Jingji Jin, Laurence Florens, Selene K Swanson, Michael P Washburn, Joan W Conaway, Ronald C Conaway

PDF

J Vis Exp. 2014 Oct25;(92): 51720.

Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes

Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway

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J Vis Exp. 2014 Oct 25;(92):e51721.

Biochemical assays for analyzing activities of ATP-dependent chromatin remodeling enzymes

Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway

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Cell. 2018 Jun 28;174(1):218-230.e13.

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen, Caitlin M Roake, Adam Freund, Pedro J Batista, Siqi Tian, Yi A Yin, Chandresh R Gajera, Shengda Lin, Byron Lee, Matthew F Pech, Andrew S Venteicher, Rhiju Das, Howard Y Chang, Steven E Artandi

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Nucleic Acids Research. 2022 Aug 10; gkac659

TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration

Lu Chen✉, Caitlin M Roake, Paolo Maccallini, Francesca Bavasso, Roozbeh Dehghannasiri, ... , Marie A Kobin, ..., Yunming Wu, ..., Maurizio Gatti, Steven Artandi, Grazia D Raffa

✉ Co-corresponding author

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