Lu Chen Lab @ Fox Chase Cancer Center
solving disease one base pair at a time
Lu Chen
Ph.D. in Biochemistry and Molecular Biology
Assistant Professor
Cancer Signaling and Epigenetics Program
Cancer Epigenetics Institute,
Fox Chase Cancer Cancer
2021-
Instructor
Stanford Cancer Institute,
Stanford University School of Medicine
2020-2021
Postdoctoral Fellow
Stanford University,
Department of Biochemistry
Department of Medicine-Hematology
Steven Artandi laboratory,
SCI fellowship in cancer research
2013-2020
Stowers Institute for Medical Research
University of Kansas Medical Center.
Joan and Ronald Conaway laboratory,
PhD Thesis: Structural and functional analysis on human INO80 chromatin remodeling complexes.
PhD (honors) in Biochemistry
2007-2013
Wuhan University and
Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Hong Tang laboratory,
Thesis: A role of CD40 and lipid rafts in atherosclerosis.
BS in Biological Sciences
2002-2006
Key Publications
Cell Rep. 2020 Feb 4;30(5):1358-1372.e5.
Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation
Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa
Cell Rep. 2020 Feb 4;30(5):1358-1372.e5.
Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation
Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa
STAR Protocols. 2021 Jun 18;2(2):100477.
Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE
Lu Chen ✉, Howard Y Chang, Steven E Artandi
✉ Co-corresponding author
DNA Repair (Amst). 2021 Jan;97:103022.
A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma
Lu Chen ✉, Rebecca R Bellone, Yan Wang, Moriel Singer-Berk, Kaoru Sugasawa, James M Ford, Steven E Artandi
✉ Corresponding author
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20497-502.
Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex
Lu Chen, Ronald C Conaway, Joan W Conaway
J Biol Chem. 2011 Apr1;286(13):11283-9.
Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling
Lu Chen, Yong Cai, Jingji Jin, Laurence Florens, Selene K Swanson, Michael P Washburn, Joan W Conaway, Ronald C Conaway
J Vis Exp. 2014 Oct25;(92): 51720.
Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes
Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway
J Vis Exp. 2014 Oct 25;(92):e51721.
Biochemical assays for analyzing activities of ATP-dependent chromatin remodeling enzymes
Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway
Cell. 2018 Jun 28;174(1):218-230.e13.
An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1
Lu Chen, Caitlin M Roake, Adam Freund, Pedro J Batista, Siqi Tian, Yi A Yin, Chandresh R Gajera, Shengda Lin, Byron Lee, Matthew F Pech, Andrew S Venteicher, Rhiju Das, Howard Y Chang, Steven E Artandi
Nucleic Acids Research. 2022 Aug 10; gkac659
TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration
Lu Chen✉, Caitlin M Roake, Paolo Maccallini, Francesca Bavasso, Roozbeh Dehghannasiri, ... , Marie A Kobin, ..., Yunming Wu, ..., Maurizio Gatti, Steven Artandi, Grazia D Raffa
✉ Co-corresponding author