News Archive

The happenings in & around the lab

Image by Juliana Malta

Oct 26, 2021

LuChenLab hosts Dr. Thomas Cech for a Distinguished Seminar on 09/22 - what a journey of discoveries and inspirations! 

2022-09-22

Within 12 years of independence at CU-Boulder, Tom's Nobel work discovered the catalytic properties of RNAs and re-wrote the central dogma. 

Tom went ahead to produce more Nobel-worth discoveries, including the discovery of TERT and Pot1. 

Tom trained numerous leading scientists, including many with deep influence on our lab: Dan Herschlag, Julie Cooper, Peter Baumann, and Jennifer Doudna with her Nobel Prize on CRISPR-Cas9.

Tom speaks for himself as "a full-time teacher" and "a teacher for life". He shared his thoughts on career and answered questions from ten Fox Chase trainees, from undergrad, graduate students, postdoc, to faculty.

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Alex joins the lab as a 1st year rotation student, welcome!

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Our first Fox Chase paper has been published in Nucleic Acids Research, Congrats Masha!

2022-08-10

    We revealed a crosstalk between 5’ cap hypermethylation and 3’ end processing underlying the biogenesis of spliceosomal RNAs (snRNA) – a step essential for motor neuron survival that is conserved among three organismal models. We found that immature snRNA (RNA snake in red) carries a mono-methylated 5’-cap and retains a 3’-extended tail containing poly-uridine; whereas, mature snRNAs (RNA snake in blue) acquire a tri-methylated cap that is catalyzed by TGS1 – the cap hypermethyltransferase – in a step that is needed for effective processing of its 3’ tail.

https://doi.org/10.1093/nar/gkac659

Media coverage: RNA Findings Could Assist in Development of New Treatments for Neurodegenerative Disorders, Cancer | Fox Chase Cancer Center - Philadelphia, PA

Lu was among the panelists of the "Together Facing Cancer and Aging" program, sharing information on the latest cancer research, treatment, and care. 

2022-06-22

Marie "Masha" Kobin will join the LuChenLab as a Summer Research Fellow - a competitive position funded by the Jeanne E. and Robert F. Ozois Undergraduate Summer Research Fellowship. Congratulations and welcome, Masha!

2022-04-12

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Lu presented a seminar in the 3rd Chromatin Club - Miami, titled
"The somatic non-coding driver mutation is repurposed from species evolution"

2022-04-05

There were ~300 or so participants, with Dr. Joana Wysocka as the keynote speaker. Lu had interactions with old and new colleagues alike - feeling good to be back into the chromatin community! Thanks for the wonderful invitation by Dr. Luis Morey, Dr. Whestine, and Active Motif.

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We hosted "Steppingstone Scholars" and provided hands-on experience for these talented, underserved Philly high schoolers

Jan 12, 2022

Students told us it is very cool to see real labs, and how the labs looked different than they expected - they also helped with various lab activities, such as miniprep and pouring agarose gels.

 

for more about these students, please visit: www.steppingstonescholars.org 

Lu Chen gave a seminar to the Department of Mechanical Engineering at Rochester Institute of Technology. 

Nov 11, 2021

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Lu Chen Lab is awarded with $200,062 from an R21 grant by NIH-NIAID, beginning 04/01/2022

April, 2022

    This grant will support the lab effort to establish RNA-centric approaches to understand noncoding RNA's roles during immune cell development and differentiation.

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Lu taught the 2021_Responsible Conduct of Research to Fox trainees, on data irreproducibility and fraud.

Oct 26, 2021

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Lu Chen Lab is hiring a Sci Tech

August, 2021

Job Qualifications

  • A Bachelor’s degree in a basic science discipline is required.

  • Experience working in a research laboratory is strongly preferred.

  • Excellent organizational skills and multitasking capacities

  • Excellent communication skills (verbal and written), interpersonal skills and a team-spirit

Job Responsibilities

  • Conduct experiments, under the supervision of the PI, in areas including but not limited to molecular cloning, cell culture, and general biochemistry techniques.

  • Order and organize laboratory supplies, maintain equipment, manage lab protocols.

  • Support research grants, and present own research.

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The fund-raising champion of the 2021 Paws for the Cause

2021-10-03

Since its first year, Paws for the Cause has raised more than $600,000 for cancer research at Fox Chase. This is the 2nd year in a row that the Whetstine team clings on to top spot. 

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Lu Chen Lab has an opening for postdoc

August, 2021

A postdoctoral position is immediately available in the Lu Chen lab of the Cancer Signaling and Epigenetic Program. The lab aims to understand in molecular details how misregulated RNA biology can contribute to human conditions, including cancer, aging, and degenerative diseases, with a long-term goal to design RNA-centric therapeutics to improve public health. We currently study RNP structure-function, RNA modifications and subcellular trafficking using multidisciplinary approaches, including RNP biochemistry, high-throughput RNA structural mapping, cell imaging, and genetic modeling in cellular and animal models.

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Lu to meet and talk with the new class of Temple graduate students

August 30, 2021

Hope the students will fall in love with the science in FCCC, and join for many lab rotations, and eventually embarking on a graduate career. 

Here is the 1-page lab intro for the student's booklet compiled by Glenn's office. 

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Soon-keat Ooi is joining from Sept, as a postdoctoral fellow and a founding member, welcome!

07/28/2021

Soon-keat received his PhD in biochemistry from the graduate school of Stowers Institute, Kansas City, with Joan and Ron Conaways.

Lu Chen Lab opens its door!

September, 2021

We are home-based in Room 246 and 247 of the West building, with our own TC room at W252, shared equipment, and cold room space. Great resources to start the journey!

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