
Publications
@Stanford University


STAR Protocols 2021; 2 (2), 100477
Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE
Lu Chen ✉, Howard Y Chang, Steven E Artandi ✉



DNA Repair (Amst). 2021 Jan;97:103022.
A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma
Lu Chen ✉, Rebecca R Bellone, Yan Wang, Moriel Singer-Berk, Kaoru Sugasawa, James M Ford, Steven E Artandi




Molecular Therapy. 2021 Mar 29;S1525-0016(21)00152-0.
Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus
Sriram Vaidyanathan, Ron Baik, Lu Chen, Dawn T Bravo, Carlos J Suarez, Shayda M Abazari, Ameen A Salahudeen, Amanda M Dudek, Christopher A Teran, Timothy H Davis, Ciaran M Lee, Gang Bao, Scott H Randell, Steven E Artandi, Jeffrey J Wine, Calvin J Kuo, Tushar J Desai, Jayakar V Nayak, Zachary M Sellers, Matthew H Porteus
bioRxiv 2021.04.28.441728
Clonal inactivation of telomerase promotes accelerated stem cell differentiation
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M.Ryan Corces, Lu Chen, Peggie Cheung, Yuning Wei, Howard Y. Chang, Steven E. Artandi

bioRxiv 356782 (doi.org/10.1101/2020.10.27.356782)
TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo
Lu Chen, CM Roake, P Maccallini, Bavasso F, R Dehghannasiri, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzui L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD



Cell Reports. 2020 Feb 4;30(5):1358-1372.e5.
Loss of human TGS1 hypermethylase promotes increased telomerase RNA and telomere elongation
Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa



Molecular Cell. 2019 May 16;74(4):688-700.e3.
Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease
Caitlin M Roake, Lu Chen, Ananya L Chakravarthy, James E Ferrell Jr, Grazia D Raffa, Steven E Artandi



Cell. 2018 Jun 28;174(1):218-230.e13.
An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1
Lu Chen, Caitlin M Roake, Adam Freund, Pedro J Batista, Siqi Tian, Yi A Yin, Chandresh R Gajera, Shengda Lin, Byron Lee, Matthew F Pech, Andrew S Venteicher, Rhiju Das, Howard Y Chang, Steven E Artandi



Nature. 2018 Apr;556(7700):244-248.
Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
Shengda Lin, Elisabete M Nascimento, Chandresh R Gajera, Lu Chen, Patrick Neuhöfer, Alina Garbuzov, Sui Wang, Steven E Artandi


Publications
@Stowers Institute for Medical Research /
Kansas University Medical Center


Proceedings of the National Academy of Sciences 2014; 111 (52), 18566-18571
Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif
Lanfeng Wang, Oliver Limbo, Jia Fei, Lu Chen, Bong Kim, Jie Luo, Jenny Chong, Ronald C Conaway, Joan W Conaway, Jeff A Ranish, James T Kadonaga, Paul Russell, Dong Wang

JoVE (Journal of Visualized Experiments) 2014, e51721
Biochemical assays for analyzing activities of ATP-dependent chromatin remodeling enzymes
Lu Chen, Soon-Keat Ooi, Joan W Conaway, Ronald C Conaway



JoVE (Journal of Visualized Experiments) 2014, e51720
Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes
Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway



Proceedings of the National Academy of Sciences 2013; 110 (51), 20497-20502
Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex
Lu Chen, Ronald C Conaway, Joan W Conaway



Journal of Biological Chemistry 2011; 286 (13), 11283-11289
Subunit Organization of the Human INO80 Chromatin Remodeling Complex AN EVOLUTIONARILY CONSERVED CORE COMPLEX CATALYZES ATP-DEPENDENT NUCLEOSOME REMODELING
Lu Chen, Yong Cai, Jingji Jin, Laurence Florens, Selene K Swanson, Michael P Washburn, Joan Weliky Conaway, Ronald C Conaway


Journal of Biological Chemistry 2013; 288 (36), 26179-26187
Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α
Dotan Sela, Juliana J Conkright, Lu Chen, Joshua Gilmore, Michael P Washburn, Laurence Florens, Ronald C Conaway, Joan Weliky Conaway


Journal of Biological Chemistry 2012; 287 (27), 23035-23045
Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α Directs Recruitment of the Mediator of RNA Polymerase II Transcription and Multiple Histone Acetyltransferase Complexes
Dotan Sela, Lu Chen, Skylar Martin-Brown, Michael P Washburn, Laurence Florens, Joan Weliky Conaway, Ronald C Conaway


Publication
@Wuhan University /
Institute of Biophysics, CAS

Arteriosclerosis, Thrombosis, and Vascular Biology. 2007; 27:2005–2013
Cholesterol-dependent and-independent CD40 internalization and signaling activation in cardiovascular endothelial cells
Jianjun Chen, Lu Chen, Gang Wang, Hong Tang
