STAR Protocols 2021; 2 (2), 100477

Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE

Lu Chen ✉, Howard Y Chang, Steven E Artandi ✉

DNA Repair (Amst). 2021 Jan;97:103022.

A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma

Lu Chen ✉, Rebecca R Bellone, Yan Wang, Moriel Singer-Berk, Kaoru Sugasawa, James M Ford, Steven E Artandi

bioRxiv 2021.04.28.441728

Clonal inactivation of telomerase promotes accelerated stem cell differentiation

Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M.Ryan Corces, Lu Chen, Peggie Cheung, Yuning Wei, Howard Y. Chang, Steven E. Artandi

bioRxiv 356782 (doi.org/10.1101/2020.10.27.356782)

TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

Lu Chen, CM Roake, P Maccallini, Bavasso F, R Dehghannasiri, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzui L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD

Cell Reports. 2020 Feb 4;30(5):1358-1372.e5.

Loss of human TGS1 hypermethylase promotes increased telomerase RNA and telomere elongation

Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa

Molecular Cell. 2019 May 16;74(4):688-700.e3.

Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

Caitlin M Roake, Lu Chen, Ananya L Chakravarthy, James E Ferrell Jr, Grazia D Raffa, Steven E Artandi

Cell. 2018 Jun 28;174(1):218-230.e13.

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen, Caitlin M Roake, Adam Freund, Pedro J Batista, Siqi Tian, Yi A Yin, Chandresh R Gajera, Shengda Lin, Byron Lee, Matthew F Pech, Andrew S Venteicher, Rhiju Das, Howard Y Chang, Steven E Artandi

Nature. 2018 Apr;556(7700):244-248.

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

Shengda Lin, Elisabete M Nascimento, Chandresh R Gajera, Lu Chen, Patrick Neuhöfer, Alina Garbuzov, Sui Wang, Steven E Artandi

Proceedings of the National Academy of Sciences 2014; 111 (52), 18566-18571

Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif

Lanfeng Wang, Oliver Limbo, Jia Fei, Lu Chen, Bong Kim, Jie Luo, Jenny Chong, Ronald C Conaway, Joan W Conaway, Jeff A Ranish, James T Kadonaga, Paul Russell, Dong Wang

JoVE (Journal of Visualized Experiments) 2014, e51721

Biochemical assays for analyzing activities of ATP-dependent chromatin remodeling enzymes

Lu Chen, Soon-Keat Ooi, Joan W Conaway, Ronald C Conaway

JoVE (Journal of Visualized Experiments) 2014, e51720

Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes

Lu Chen, Soon-Keat Ooi, Ronald C Conaway, Joan W Conaway

Proceedings of the National Academy of Sciences 2013; 110 (51), 20497-20502

Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex

Lu Chen, Ronald C Conaway, Joan W Conaway

Journal of Biological Chemistry 2011; 286 (13), 11283-11289

Subunit Organization of the Human INO80 Chromatin Remodeling Complex AN EVOLUTIONARILY CONSERVED CORE COMPLEX CATALYZES ATP-DEPENDENT NUCLEOSOME REMODELING

Lu Chen, Yong Cai, Jingji Jin, Laurence Florens, Selene K Swanson, Michael P Washburn, Joan Weliky Conaway, Ronald C Conaway

Journal of Biological Chemistry 2013; 288 (36), 26179-26187

Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α

Dotan Sela, Juliana J Conkright, Lu Chen, Joshua Gilmore, Michael P Washburn, Laurence Florens, Ronald C Conaway, Joan Weliky Conaway

Journal of Biological Chemistry 2012; 287 (27), 23035-23045

Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α Directs Recruitment of the Mediator of RNA Polymerase II Transcription and Multiple Histone Acetyltransferase Complexes

Dotan Sela, Lu Chen, Skylar Martin-Brown, Michael P Washburn, Laurence Florens, Joan Weliky Conaway, Ronald C Conaway

Arteriosclerosis, Thrombosis, and Vascular Biology. 2007; 27:2005–2013

Cholesterol-dependent and-independent CD40 internalization and signaling activation in cardiovascular endothelial cells

Jianjun Chen, Lu Chen, Gang Wang, Hong Tang