Lu Chen Lab @ Fox Chase Cancer Center
solving disease one base pair at a time
Publications @
Fox Chase Cancer Center
4. Murayama T, Nakayama J, Jiang X, Miyata, K, Morris AD, Cai QK, Prasad RM, Ma X, Efimov A, Belani N, Gerstein ER, Tan Y, Zhou Y, Kim JW, Maruyama R, Campbell KS, Chen L, Yang Y, Balachandran S, Canadas I.
Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in Small Cell Lung Cancer
Cancer Discovery, accepted 12/15/2023, https://doi.org/10.1158/2159-8290.CD-23-0486
3. Huda A, Arakawa H, Mazzucco G, Galli M, Petrocelli V, Casola S, Chen L, Doksani Y.
The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats.
Science Advances. 2023 Mar 22;9(12):eadf2011.
2. Chen L ✉, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Galati A, Palumbo V, Kobin MA, Tartaglia GG, Colantoni A, Proietti G, Wu Y, Hammerschmidt M, De Pittà C, Sales G, Salzman J, Pellizzoni L, Wirth B, Schiavi ED, Gatti M, Artandi SE, Raffa GD. TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Nucleic Acids Research 2022 Aug 10:gkac659. doi: 10.1093/nar/gkac659. Epub ahead of print. PMID: 35947650.
(✉ co-corresponding, selected for NAR cover art_Vol 50, Issue 21, Nov 28, 2022)
1. Galati A, Scatolini L, Micheli E, Bavasso F, Cicconi A, Maccallini P, Chen L, Roake CM, Schoeftner S, Artandi SE, Gatti M, Cacchione S, Raffa GD. The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening. FEBS Lett. 2022 Jan;596(1):42-52. doi: 10.1002/1873-3468.14240. Epub 2021 Dec 5. PMID: 34817067.
Publications
@Stanford University
Molecular Therapy. 2021 Mar 29;S1525-0016(21)00152-0.
Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus
Sriram Vaidyanathan, Ron Baik, Lu Chen, Dawn T Bravo, Carlos J Suarez, Shayda M Abazari, Ameen A Salahudeen, Amanda M Dudek, Christopher A Teran, Timothy H Davis, Ciaran M Lee, Gang Bao, Scott H Randell, Steven E Artandi, Jeffrey J Wine, Calvin J Kuo, Tushar J Desai, Jayakar V Nayak, Zachary M Sellers, Matthew H Porteus
bioRxiv 356782 (doi.org/10.1101/2020.10.27.356782)
TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo
Lu Chen, CM Roake, P Maccallini, Bavasso F, R Dehghannasiri, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzui L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD
Cell Reports. 2020 Feb 4;30(5):1358-1372.e5.
Loss of human TGS1 hypermethylase promotes increased telomerase RNA and telomere elongation
Lu Chen, Caitlin M Roake, Alessandra Galati, Francesca Bavasso, Emanuela Micheli, Isabella Saggio, Stefan Schoeftner, Stefano Cacchione, Maurizio Gatti, Steven E Artandi, Grazia D Raffa
Cell. 2018 Jun 28;174(1):218-230.e13.
An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1
Lu Chen, Caitlin M Roake, Adam Freund, Pedro J Batista, Siqi Tian, Yi A Yin, Chandresh R Gajera, Shengda Lin, Byron Lee, Matthew F Pech, Andrew S Venteicher, Rhiju Das, Howard Y Chang, Steven E Artandi
Publications
@Stowers Institute for Medical Research /
Kansas University Medical Center
Proceedings of the National Academy of Sciences 2014; 111 (52), 18566-18571
Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif
Lanfeng Wang, Oliver Limbo, Jia Fei, Lu Chen, Bong Kim, Jie Luo, Jenny Chong, Ronald C Conaway, Joan W Conaway, Jeff A Ranish, James T Kadonaga, Paul Russell, Dong Wang
Journal of Biological Chemistry 2011; 286 (13), 11283-11289
Subunit Organization of the Human INO80 Chromatin Remodeling Complex AN EVOLUTIONARILY CONSERVED CORE COMPLEX CATALYZES ATP-DEPENDENT NUCLEOSOME REMODELING
Lu Chen, Yong Cai, Jingji Jin, Laurence Florens, Selene K Swanson, Michael P Washburn, Joan Weliky Conaway, Ronald C Conaway
Highlighted in “Milestones in transcription and chromatin published in the Journal of Biological Chemistry”, 2019 Feb 1;294(5):1652-1660.
Journal of Biological Chemistry 2013; 288 (36), 26179-26187
Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α
Dotan Sela, Juliana J Conkright, Lu Chen, Joshua Gilmore, Michael P Washburn, Laurence Florens, Ronald C Conaway, Joan Weliky Conaway
Journal of Biological Chemistry 2012; 287 (27), 23035-23045
Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α Directs Recruitment of the Mediator of RNA Polymerase II Transcription and Multiple Histone Acetyltransferase Complexes
Dotan Sela, Lu Chen, Skylar Martin-Brown, Michael P Washburn, Laurence Florens, Joan Weliky Conaway, Ronald C Conaway
Publication
@Wuhan University /
Institute of Biophysics, CAS
